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Neurotrophic and neuroprotective actions of estrogen: basic mechanisms and clinical implications

Damiani, C

Additionally, early nonmotor symptomssuch as anosmia, REM sleep behavior disorder (RBD), and gastrointestinal dysfunctionare increasingly identified as prodromal indicators

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Significant weight loss (at least 10% of body weight) reduces HbA1c, blood pressure, lipid levels [88], and the incidence of MACEs including cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, and hospitalized angina by up to 21% in T2DM patients