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GLP-1 medications are not recommended during pregnancy or breastfeeding, and some (like semaglutide) should be discontinued at least 2 months before a planned pregnancy

GIP signalling has been implicated in both central and peripheral metabolic regulation, and may interact with reward pathways in ways that differ from or complement GLP-1 signalling

Semaglutide works by slowing stomach emptying and signaling satiety to your brain, helping reduce hunger and calorie intake

However, starting with a low dose and titrating slowly allows your gut to adapt

This has prompted investigation into higher-potency GLP-1RAs and monotherapy approaches, including dual incretin agents such as tirzepatide, to assess whether stronger metabolic effects can be achieved in this age group

Biological function analysis The rHrGSTm1 had certain scavenging ability to DPPH