GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) targets hair follicle biology through mechanisms neither of those compounds address: dermal papilla cell proliferation, follicle stem cell recovery, and TGF-beta1 suppression
The safety profile, optimal dosing strategies, and long-term effects in humans have not been fully established
The strategy of covalently conjugating metal-based anticancer agents to amphiphilic polymers, that could self-assemble into nanoparticles, could present a method for the tumor-selective anticancer therapy
The most common adverse effect involves scalp irritation, occurring in 5-10% of users and typically presenting as itching, dryness, flaking, or dermatitis
Challenges to safe nanomedicine treatment
This indirect mast cell stabilization helps to reduce the frequency and severity of allergic-like reactions, flushing, and sudden heart rate spikes