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True non-response can occur when patients carry genetic variants that reduce GLP-1 or GIP receptor function, or when undiagnosed metabolic conditions such as hypothyroidism or polycystic ovary syndrome interfere with treatment efficacy

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Notably, thousands of cases have already been consolidated into federal MDLs, reflecting the scale and complexity of this emerging mass tort

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This provides a clear view into how these therapies are being integrated into diabetes care at scale and highlights the value of Marketplace data for tracking treatment adoption and patient outcomes in real time (Figure 1)