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A 2014 paper in the International Journal of Colorectal Disease reported a Phase 2 randomized controlled trial of ipamorelin for the management of postoperative ileus in bowel-resection patients, providing one of the few human-clinical-trial datasets for this class of molecule (PMID 25331030)

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Despite their overlapping features, the underlying pathophysiological mechanisms of abdominal pain in FC remain poorly understood, and it is unclear whether the pain mechanisms in FC resemble those in IBS-C or arise from distinct processes [16, 17]

No major adverse effects been reported

Tang D, Kroemer G

The antioxidants in beetroot shield against UV rays, one of the main causes of skin ageing