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Frias et al., The Lancet, 2021 (SURPASS-2) Unprecedented Healthy Weight Loss Achieve profound, sustainable weight loss

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Why the Field Still Lacks Mechanistic Clarity The inability to establish a reproducible mechanistic model does not reflect a deficit of data, intelligence, or investment

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These studies were also designed to determine whether the typical plateau of weight loss that occurs with any pharmacotherapy intervention 22,23,40,41,46,52,54,75 , even combinatorial therapies 33,50,51 could be overcome through a unique stepwise approach of introducing the combinatorial therapy in attempt to overcome the tachyphylaxis of sustained pharmacotherapy administration from the beginning of treatment

Velichkovsky BB, Razvaliaeva AY, Khlebnikova AA, Manukyan PA, Kasatkin VN, Barmin AV