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GHK-Cu was also shown to play a role in ischemic and diabetic wound healing in rats, as well as decreasing TNF-alpha levels and increasing collagen synthesis ( Anti-Inflammatory Effects of GHK-Cu As it was mentioned above, GHK-Cu is shown to have antioxidant and anti-inflammatory properties

However, the daily dose for the mice in this study was 100mg/kg

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Hence, additional data are needed to establish the optimal dose adjustment in patients with moderate hepatic impairment

The applicant also noted Anderson et al

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