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demonstrated that BPC-157 modulates dopamine D2 receptors and interacts with the serotonergic system in rats (Sikiri et al., J Physiol Paris, 1999)

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Gastrointestinal adverse events occurred in 79.6% of CagriSema participants versus 39.9% with placebo, were mostly transient, and led to discontinuation in 6-8.4% of participants

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or R 3 and R 5 together form an optionally substituted C 3 -C 6 cycloalkyl ring, optionally substituted C 2 -C 7 heterocycloalkyl ring, optionally substituted C 6 -C 10 aryl ring, or an optionally substituted C 3 -C 9 heteroaryl ring