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One particularly intriguing question is why SNpc DA neurons should be particularly susceptible to propagated aSYN aggregates

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Antagonizing D2-like receptors with haloperidol restored biomarkers of RA, including serum rheumatoid factor, matrix metalloprotinease-3, serum IgG, and antinuclear antibody to normal levels in adult female albino rats (Fahmy Wahba et al., 2015), suggesting activation of D2-like receptors dysregulates these factors