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Ethics declarations This paper is devoid of any conflict of interest

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Never touch the needle itself with your bare fingers, and keep the needle away from any contaminated surfaces

Finally, although some improvement from baseline was still observed in all assessed cardiometabolic parameters despite partial weight regain of up to 50% after 1 year of tirzepatide withdrawal, these findings support the importance of long-term maintenance of weight reduction through lifestyle intervention and obesity management medications to sustain cardiometabolic benefits and improved health-related quality of life

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