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The Pcob specific C-terminal five-helix globin domain does not contribute directly to the dimer interface, and is positioned such that it forms interactions with both of the B 12 -binding domains (i.e., Rossmann fold and four-helix bundle)
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Likewise, for bone morphogenic proteins (BMPs), at that time, besides bone matrix, the following biomaterials have been tested as carriers: calcium phosphate, collagen, gelatin, and starch (Miyamoto et al., 1992
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