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Immune effects are restorative, not overstimulating: It rebalances T-cell ratios, upregulates IL-2 in aged tissues, and improves neuroimmune integration, suggesting a targeted recalibration of immune tone rather than indiscriminate boosting. It restores circadian and hormonal rhythms: By stimulating melatonin synthesis, protecting pineal structure, and re-entraining clock genes, Epitalon may counter the widespread circadian drift of aging, with implications far beyond sleep, touching immunity, metabolism, and neuroprotection

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This reduction in viscoelasticity can compromise the ligaments ability to recover from deformations, increasing the risk of a complete tear during sudden movements or impacts

However, data are scant and controversial, resulting in limited efforts to study the effect of nutritional interventions on GSH status