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One study suggested that GLP-1RAs exert direct endothelial protective effects by activating the GLP-1R-dependent AMPK/Akt/eNOS pathway

The connection between delayed gastric emptying and altered intestinal movement highlights that these symptoms are not unexpected complications but rather a known part of how the therapy functions

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This has become enough of a recognised pattern that the supplement industry is actively building products specifically aimed at GLP-1 users to help cover these gaps

[DOI] [PubMed] [Google Scholar] 65.Nowowiejska J., Baran A., Flisiak I