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Evaluation of the efficacy and safety of adjuvant treatment to levodopa therapy in Parkinson s disease patients with motor complications

GHK-Cus gene modulation capacity was documented in a landmark microarray analysis by Pickart et al., identifying 4,000+ gene targets including VEGF upregulation (angiogenesis), SOD2 upregulation (oxidative defense), and downregulation of pro-inflammatory cytokine genes including TNF- and IL-6

Patients were assessed at baseline and 30 days post-treatment, with follow-up extending to three months

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A clinical study demonstrated that GPNA suppressed the expression of ASCT2 and diminished the uptake of Gln by cancer cells [169]

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