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It is advisable to incorporate physical activity and ensure adequate protein intake to help mitigate muscle loss and enhance overall health during the treatment process

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Disturbed mitochondrial transport along motor neuron axons and defective mitophagy are among the earliest pathophysiological events [120]

After discontinuing semaglutide but continuing metformin for two years, they regained only one-third of their lost weight , with 21 out of 25 women maintaining a lower weight than their starting baseline