This represents a clinically meaningful outcome that could substantially impact long-term health trajectories
Some depressed patients were also reported to have enlarged adrenal glands (253,254) and impaired negative feedback with the hypercortisolemia, thereby suggesting that the level of impairment is at the glucocorticoid receptor-dependent negative feedback, either centrally or at the level of pituitary (255,256)
doi:10.1016/j.arth.2022.03.003 Kulkarni K, Karssiens T, Kumar V, Pandit H
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