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It was discovered by Russian scientist Professor Vladimir Khavinson in the 1980s
Understanding the Problem: In women with androgenetic alopecia, androgens like testosterone and DHT cause progressive damage to hair follicles: Androgens bind to receptors in scalp hair follicles This binding triggers follicle miniaturization follicles gradually shrink Miniaturized follicles produce thinner, shorter, weaker hair Over time, follicles may stop producing visible hair altogether This is why hair gradually becomes finer and thinner in female pattern hair loss How Spironolactone Intervenes: Step 1: Blocks Androgen Receptors Spironolactone acts as an androgen receptor antagonist it occupies the receptors that androgens would normally bind to, preventing them from triggering follicle miniaturization
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Selective oestrogen receptor modulation: molecular pharmacology for the millennium
Methods Pediatric oncology patients (n=100) completed PROMIS Pediatric item banks for Anxiety v3.0, Depressive Symptoms v3.0, Peer Relationships v3.0, Mobility v3.0, Fatigue v3.0, and Sleep Disturbances v1.0, as well as Global Health v1.0 scale, Anger 9a v3.0 short form, and Pain Intensity item v1.0
But allow 2-4 weeks between peptides to assess individual responses and avoid overlapping effects
