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We are seeing that if you do that approach, its safe, more patients are able to complete all the therapy lines, and we are noticing an increase in pathologic complete response rates. Pathologic complete response describes the absence of any detectable cancer cells in a tissue sample following a particular treatment

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[DOI] [PMC free article] [PubMed] [Google Scholar] 76.Ezugha H, Goldenthal M, Valencia I, Anderson CE, Legido A, Marks H

First of all, the dual role of the gastrointestinal system - dedicated not only to nutrient absorption from the lumen, but also to their supply to other tissues via the blood - may present one of the reasons for the intestine-specific susceptibility to TD