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The most common side effects include nausea, upset stomach, constipation, fatigue, and headaches, which typically resolve with time
Animal studies have shown potential risks with GLP-1 drugs during pregnancy, and these medications should be discontinued before conception if possible
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Importantly, LBM remained largely stable, with slight gains in leg and arm FFM in some patients, resulting in minimal changes in skeletal muscle index and no cases of sarcopenia
Many gastrointestinal side effects may decrease as treatment continues, but there is no guaranteed week when they disappear
A strong letter of medical necessity should include: your BMI history over at least 12 months, documentation of weight-related comorbidities (hypertension, type 2 diabetes or prediabetes, dyslipidemia, sleep apnea), prior weight-loss attempts and their outcomes, the specific clinical trial data supporting the requested medication, and a statement that the medication is medically necessary (not cosmetic)
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