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Foundational work appears in journals including Lancet HIV, AIDS, and JCEM, with multiple phase 2 and phase 3 clinical research papers examining endpoints in HIV-associated lipodystrophy and visceral adipose tissue research.

Loren Pickart's foundational 1973 characterization of GHK as a plasma growth-promoting peptide opened a research line that now extends across wound healing, skin remodeling, antioxidant gene expression, and anti-inflammatory regulation [9,10]

Footnotes Edited by Wang XL and Xu FM Proofread by Zhu LH References 1.Sikiric P, Petek M, Rucman R, Seiwerth S, Grabarevi Z, Rotkvi I, Jagi V, Turkovi B, Mildner B, Duvnjak M

Watts T, Berti I, Sapone A et al (2005) Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats

Current anti-obesity pharmacotherapy includes 5 FDA-approved medications: orlistat, phentermine-topiramate, naltrexone-bupropion, liraglutide, and semaglutide (Table 2), as well as phentermine, which is approved only for short term use

One study found that people who drank more caffeinated drinks were slightly less likely to gain weight than those who cut down on coffee and tea