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GPx4 uses the reducing power of glutathione to convert highly toxic lipid hydroperoxides into harmless, non-toxic lipid alcohols

Further doseresponse and steady-state administration studies will be required to optimize the dosing schedule for future trials to evaluate therapeutic efficacy

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For instance, in SH-SY5Y neurons, 27-OHC activates the TGF-/NF-B signaling pathway, inducing TNFa production and iNOS expression, while suppressing IL-10 production (Ma et al., 2019)