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Although there was limited information on its cardioprotective effects, much evidence suggests Moringa oleifera extracts can significantly decrease pro-inflammatory and apoptotic markers such as TNF-, IL-1, IL-6, NF-, caspase 3, caspase 9, and tumor protein (p53) to alleviate the detrimental effects of hyperglycemia in preclinical models of T1D (Muhammad et al., 2016

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Meanwhile, previous studies have reported that NO can disrupt autophagy by the SNO of different proteins, including the components of the mTOR signaling pathway [284]

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