Patients should never increase their dose more rapidly than recommended, as this significantly increases the risk of gastrointestinal side effects
Sections were stained with hematoxylin and eosin (H&E), wheat germ agglutinin (FITC-conjugated, Merck Life Science Oy, UK) and Picro-Sirius red (Abcam, # ab245887) to measure cell size and cardiac fibrosis level in the LV free wall at the level of the papillary muscles
Losing ten pounds of muscle instead of fat means burning 500 fewer calories daily, making continued weight loss progressively more difficult
In HFrEF, the administration of GLP-1 RAs did not improve LV systolic function
BPC 157 is a pentadecapeptide, a sequence of 15 amino acids derived from a protective protein found in the stomach
The rationale is that weight loss beyond 15% often produces clinically meaningful improvements in joint symptoms, and retatrutide consistently crosses that threshold at moderate doses