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E., Patel N., Sahler L

Alternatives in Class At a glance Brand Vyvanse (30-day supply) / $350 to $450 cash price Generic lisdexamfetamine (30-day supply) / $30 to $80 cash price (since August 2023) Generic mixed amphetamine salts XR / $15 to $50 per month Generic methylphenidate ER / $20 to $45 per month FDA-approved indications / ADHD (ages 6+) and binge eating disorder (adults) Duration of action / 12 to 13 hours in controlled trials DEA schedule / Schedule II controlled substance Prodrug conversion / Lisdexamfetamine is cleaved to d-amphetamine in red blood cells Patent expiration / August 2023 (first generics launched) Insurance tier / Tier 2 to 3 for generics

discuss testing and options with a clinician

Ohtsuka et al., 1986

These are the findings of a new study funded by Eli Lilly, which makes both Trulicity and Mounjaro

Instead of relying on a single mechanism, these therapies coordinate multiple hormonal systems that naturally regulate metabolism