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Semaglutide, a long-acting GLP-1 agonist, exhibited a sustained weight decrease of approximately 15% of body weight in clinical studies, whereas tirzepatide, a combination GIP/GLP-1 agonist, attained a weight loss of up to 22.5% in the SURMOUNT trials [36,37]

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Notably, six of those metabolites were subsequently also detected in blood cell samples of human volunteers after ingestion of multiple doses of 200 and 300 mg Pycnogenol (28)