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Further prospective and randomised studies are needed to clarify any relationship between GLP-1 receptor agonists and glaucoma, as well as their long-term ocular safety

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In some cases, these drugs were studied at dose strengths that may not be available with off-label use

Verma, S., & McMurray, J

Suppressed macrophage infiltration followed by reduced macrophage foam cell formation by active forms of GLP-1 and GIP was demonstrated by Nagashima M, et al

(2025) Osteoarthritis and Cartilage n=342 Phase 3 trial evaluating retatrutide versus placebo for knee osteoarthritis in obese subjects, measuring WOMAC scores, joint space narrowing, and pain reduction