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Following the successes of GLP-1 RAs, manufacturers have worked to produce similar outcomes with newer agents that affect the incretin pathways including not only GLP1 receptors but also GIP and glucagon receptors

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These medications are contraindicated in patients with: Personal or family history of medullary thyroid carcinoma (MTC) Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Severe gastrointestinal disease They are not recommended in patients with severe gastrointestinal disease (e.g., gastroparesis)

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