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In 2012, the criteria were revised by the Systemic Lupus International Collaborating Clinics (SLICC).[1] Using the SLICC criteria, SLE is diagnosed if the patient has either of the following over time: Four criteria including one clinical criterion and one immunological criterion Biopsy-proven lupus nephritis and antinuclear antibodies or anti-double-stranded DNA antibodies These criteria depend on history, clinical examination, exclusion of other causes of the symptoms, and the results of investigationsincluding blood tests and biopsy of the affected tissue

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