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Finkelstein, A

Results A phenotypic screen identifies electrophilic compounds with senolytic activity To identify vulnerabilities of senescent cells, we took advantage of a library of electrophilic compounds (Methods) to conduct a senolytic screen (Fig

An invention was submitted for a patent on 12 November 1996 [7], and the scientific article was submitted for publication in the Journal of Clinical Investigation 20 June 1997 and published 1st February 1998 [6]

Quantification of the plateau (middle) and the rate of ligand-induced conformational change (right) for each agonist (1 M GLP-1 and 10 M TT-OAD2) was calculated by applying a one-phase association curve to the kinetic data with values from each individual experiment show in black circles

V., & Triplett, W

Safety Toxicity The Food and Nutrition Board did not set a tolerable upper intake level (UL) for thiamin because there are no well-established toxic effects from consumption of excess thiamin in food or through long-term, oral supplementation (up to 200 mg/day)