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Other side effects can include occasional bloating, mild constipation, or fatigue

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Synonyms Berberis acida and European barberry

Age 65 or Greater: The risk of metformin-associated lactic acidosis increases with the patients age because elderly patients have a greater likelihood of having hepatic, renal, or cardiac impairment than younger patients

Ala 21 The mutation of GLP-1 Glu 27 to Ala does not change the affinity but slightly increases activity

They stimulate insulin secretion from pancreatic beta cells in a glucose-dependent manner, meaning insulin is released only when blood glucose levels are elevated