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In addition, changes in metabolites in the tumor microenvironment are important causes of drug resistance

The key regulatory milestones: FDA Breakthrough Therapy designation for MASH (September 2024) EMA PRIME designation for MASH (November 2023) China NMPA Breakthrough designation (June 2024) Phase 3 trials (SYNCHRONIZE-1 and SYNCHRONIZE-2) fully enrolled, results expected H1 of this year Estimated FDA filing: Late this year at the earliest Estimated FDA approval: Possibly next year, depending on Phase 3 results If Phase 3 results confirm Phase 2 findings, survodutide could reach the market within the next 12-24 months

What Some Of The Evidence Shows So Far A 2025 brief case series using modelling examined less frequent dosing of GLP-1s for weight maintenance

Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes

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You fix what's broken, maintain what's working, and stop throwing resources at problems that live somewhere else