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In addition to its comedolytic, sebum-regulating, and anti-inflammatory properties, it appears capable of inhibiting extracellular matrix metalloproteinases and increasing collagen type I and III production.7 In a prospective study, 20 individuals were administered oral isotretinoin 20mg 3 times a week for 12 weeks

J.NemotoK.NishikawaT.MatsushimaK.MinamiM.KawaseM