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Several commenters noted the limited health IT infrastructure available to report the measure, particularly for smaller and rural hospitals, which presents significant barriers to implementation

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Prostaglandins, including prostaglandin E2 (PGE2), play a role in triggering inflammation in tissues and creating an environment that encourages tumor development (23)

Suvorexant, for example, is a drug targeting orexin receptors, highlighting the feasibility of this approach