A detailed review of literature has found increased oxidative stress in acute as well as chronic infections of the ear, nose, and sinuses and the rationale for adding an antioxidant to the therapy (126)
Also, baicalin was shown to prevent ferroptosis in erastin-treated PANC1 cells (a human pancreatic cancer cell line) by reducing ferrous iron, inhibiting GSH depletion, and suppressing GPX4 degradation, thereby inhibiting lipid peroxidation [369]
They are commonly included in longevity and performance optimization protocols
In man, UA is the final product of purine catabolism ( DUAL ROLES OF URIC ACID IN AODS Contrary to the traditional understanding as a metabolically inert and waste compound without any physiological significance, UA is a natural antioxidant contributing to approximately 60% of the free radical scavenging activity in human blood ( Uric acid is a selective antioxidant ( Figure 3 ) that removes superoxide by preventing the degradation of superoxide dismutase and subsequently inhibits its reaction with NO to form peroxynitrite ( + -induced depolarization amplifies neuroprotection provided by UA through a mechanism involving Ca 2 elevation and extracellular signal-regulated kinases (ERK 1/2 ) activation ( Figure 3 )
Maintaining adequate levels may help your immune system stay calibrated rather than overreacting to threats
Ronnemaa E, Zethelius B, Lannfelt L, Kilander L
