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Many practitioners start newer patients on the 600mg dose, then move to 1200mg for those wanting a stronger effect or continuing an existing treatment plan

For example, methapyriline increases liver weight and the number of hepatocyte mitochondria in treated mice, with development of hepatotoxicity and liver neoplasia probably secondary to oxidative damage (Powell et al

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This has led to the hypothesis that elevations in GGT reflect increasing xenobiotic-GSH conjugation, including POPs,with preliminary evidence linking GGT levels to polycyclic aromatic hydrocarbon exposure