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These challenges include degradation by cellular nucleases, high renal clearance, and low penetration in biological membranes due to their negative charge

the Excellence project PrF UHK 2217/2022-2023 Czech Republic

10.1093/hmg/ddw379 Hum

It was found that GCH1 overexpression selectively protected phosphatidylcholines with two PUFA tails from oxidative degradation, and these phospholipids drove ferroptosis, thereby protecting cells from ferroptosis

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