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Quantification of IECs double-positive for epithelial cell adhesion molecule (EpCAM) and GLP-1 by flow cytometry showed no differences between Tmprss2 / and WT mice, indicating regulation of GLP-1 secretion (Supplemental Figure 4, C and D)

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Sedentary work environments, irregular eating patterns, and chronic stress contribute to rising levels of obesity, fatty liver disease, and insulin resistance

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This is why the relationship between GLP-1 and gut microbiome function matters, because slower transit, altered fermentation, and microbial shifts can all influence digestive comfort during treatment