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To mitigate this drawback, the pharmacological administration of GIP, primarily known for its insulinotropic and mild appetite-suppressing properties [7], is also suggested to have an anti-emetic effect, potentially allowing GIP co-agonism to increase tolerability to the GLP-1 component [8]

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The article attributes the spread to operational costs that vary by region and facility: sterile facility licensing, quality control testing, pharmacist oversight, and cold-chain logistics

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