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6 / 13 B12 deficiency is rare because your body can store several years supply of the stuff

That can introduce variability such as: Mislabeling Contamination Inconsistent dosing Unknown impurities Side effects: what we can responsibly say Because robust human safety data are limited, it's hard to give a definitive side-effect profile with meaningful incidence rates

Polycythaemia Vera: Treatment with B12 can mask the diagnosis of this blood disorder, so careful monitoring is necessary if B12 is started before a complete diagnosis

Unwanted weight and constant fatigue often go handinhand

The evidence is preclinical (mouse and cell studies)

As a result, structured storage methods continue improving scientific reliability and analytical efficiency