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104,105,106 Over a decade ago, an in vitro study revealed that a combination of specific transcription factorsGATA4, MEF2C and TBX5 (collectively referred to as the GMT cocktail)could directly reprogram fibroblasts into functional cardiomyocytes, bypassing the conventional iPSC stage

Petrylak, D

At room temperature (15-25 degrees Celsius), expect 3-6 months of reliable stability, though this is the least recommended long-term storage option

The gene therapy was approved via the FDAs accelerated approval pathway based on data that established it increased the expression of the Elevidys micro-dystrophin protein

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