In my previous Substack posts, we've unpacked the transformative power of GLP-1 medicationshow they work, why they're so effective against obesity, and how physicians like myself carefully use them off-label to tackle metabolic dysfunction at its core
Diabetes Therapy , 14 (5), 1243-1257
This method is particularly effective for comprehensive absorption and offers the advantage of adjusting dosages according to individual tolerance and response
And now, here are your tidbits
Appendix 3 (available at www.cmaj.ca/lookup/doi/10.1503/cmaj.250502/tab-related-content) provides additional context for several recommendations (subpopulations with heart failure with preserved ejection fraction [HFpEF], metabolic dysfunctionassociated steatohepatitis (MASH), obstructive sleep apnea [OSA], and osteoarthritis, and for those with rare genetic monogenic causes of obesity)
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