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In general, these side-effects subside quickly

The process of melanogenesis, or melanin synthesis, involves complex enzymatic reactions within melanocytes, with tyrosinase being the key enzyme responsible for converting the amino acid tyrosine into melanin

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It also accelerates growth during the active phase of the hair follicle cycle by promoting the migration of stem cells to the base of the hair follicles [2]

This assumption was verified in a follow-up study that activation of anti-viral responses by polyinosinic-polycytidylic acid attenuated APAP-induced hepatotoxicity through transcriptional down regulation of RXR and PXR and their downstream CYPs [34]