[DOI] [PubMed] [Google Scholar] 122.Balantekin K.N., Kretz M.J., Mietlicki-Baase E.G
Preserved incretin effect in type 1 diabetic patients with end- stage nephropathy treated by combined heterotopic pancreas and kidney transplantation
NICE technology appraisals TA875 (semaglutide 2.4mg/Wegovy) and TA664 (liraglutide 3mg/Saxenda) support their use specifically for weight management in adults within specialist weight management services
O mecanismo proposto envolve reduo da hiperinsulimenia, modulao do IGF-1 e possveis efeitos anti-inflamatrios diretos nos receptores GLP-1 expressos em clulas do clon
The latter include synaptic protection, improvements in cognition, learning and motor function, amyloid pathology-ameliorating properties (A, Tau, and -synuclein), the suppression of Ca 2+ deregulation and ER stress, potent anti-inflammatory effects, the blockage of oxidative stress, mitochondrial dysfunction and apoptosis pathways, enhancements in the neuronal insulin sensitivity and energy metabolism, functional improvements in autophagy and mitophagy, elevated BDNF and glial cell line-derived neurotrophic factor (GDNF) synthesis as well as neurogenesis
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