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Clinical trials show that approximately 10-15% of patients may be considered "non-responders" who lose less than 5% of body weight after 3-4 months on a maintenance dose

Statistical significance was calculated by two-way ANOVA followed by Dunnetts multiple comparisons test with Bmal1 -KO set as the reference group in a (right panel), and a and d , and ANCOVA in b , and one-way ANOVA followed by multiple comparisons in e-g

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