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The latest trials demonstrated weight loss of up to nearly 23 percent of starting body weight - positioning retatrutide as perhaps the most powerful weight loss drug yet developed for adults with heart disease or type 2 diabetes

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A loss of 10 to 15% of your starting body weight is considered clinically meaningful and is associated with improvements in blood pressure, blood sugar, cholesterol, and joint health

Cui J, Das DK, Bertelli A, Tosaki A (2003) Effects of L-Carnitine and its derivatives on postischemic cardiac function, ventricular fibrillation and necrotic and apoptotic cardiomyocyte death in isolated rat hearts