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The durability of vaccine protection is another key area that requires a better understanding of the fundamentals of immune memory, a key question being how can we limit the acute contraction of the adaptive immune response after prophylactic vaccination and limit attrition of long-term memory , in particular for nAb titers in the blood?

We measured body weight every day for 38 days

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Induction of HO-1 expression in dendritic cells inhibits them maturation and secretion of pro-inflammatory cytokines and promotes regulatory T cell (T reg cell) responses