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Table 1 Potential therapeutic agents targeting bile acid metabolism in gout: FXR antagonists and TGR5 agonists

Hippocampal neurons were then cultured a further 3-7 days, at which time they were either transfected or treated with various pharmacological reagents as described in (Wayman et al., 2008)

However, it was found that obese people are hyperleptinaemic, develop central leptin resistance and are unresponsive to leptin therapy [72]

Internal audits help identify any non-compliance issues and provide an opportunity to correct them before external inspections