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PlexusDx's Precision Peptide Genetic Test analyzes 14 peptide pathways including GLP1R and GIPR variants, which can indicate individual sensitivity to tirzepatide's effects on gut motility and water absorption
However, although commonly reported by patients, these symptoms are mostly mild, are rarely a reason for discontinuation of therapy, and seem to decrease over time with ongoing treatment.7,25e27 Although gastrointestinal side-effects occurred commonly in the large cardiovascular outcome trials, most were reported in the first weeks after initiation and they only led to discontinuation of treatment in 1e3% of cases.10,11 On the ICU, GLP-1 was also found to decrease gastric motility, although its effect was minimal when gastric emptying was already delayed.28 In patients with diabetes mellitus, gastroparesis is a known complication that requires attention and appropriate action by anaesthesiologists
Zhao J, et al
Not everyone who takes GLP-1 medications will experience these symptoms
