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While the 0.18% difference in hemoglobin A1C between the doses was statistically significant, elsewhere a decline in hemoglobin A1C of at least 0.5% has been considered clinically meaningful

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doi: 10.1016/j.mehy.2020.110102 37 Cerqueira BorgesR.Sayuri HohmannM.MarquesB

Statins and Ozempic are a common and generally well-tolerated combination

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In clinical practice, some prescribers begin at 1mg or even 0.5mg as a pre-titration step before entering the 2mg phase, particularly for patients with a history of GI sensitivity on GLP-1 medications