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Oral L-citrulline has high intestinal absorption but minimal first-pass metabolism and renal reabsorption (Shearer et al., 1997)

Healthspan is thus distinct from extending life expectancy, or lifespan (longevity), which can be readily quantified, and is defined as the length of time an organism lives, or total lifespan

Not as isolated problems

Participants were given GLP-1RA (starting dose 0.6 mg/day, increasing weekly to a maximum of 1.8 mg/day) or placebo alongside standard care

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Both the EP and P groups exhibited statistically significant reductions in LDL cholesterol, serum insulin, and HOMA-IR when compared to the control group, with a notable decrease in serum resistin observed exclusively in the P group